Newly forming HIV virions embedded in the leading edge of dynamic filopodia.
HIV infection of dendritic cells and other cells of myeloid lineage provides a potent reservoir from which HIV can later seed CD4 T cells. In dissecting the mechanisms of viral transfer from HIV-infected dendritic cells to CD4 T cells, a dynamic structure consisting of newly formed HIV virions being launched by probing filopodia was observed (see Aggarwal et al., doi:10.1371/journal.ppat.1002762). HIV incorporation into the tips of dendritic cell filopodia is observed in the image, with HIV particles in white and filopodial networks in red visualised by F-actin staining. Nuclear staining by DAPI is presented in blue.
Image Credit: Anupriya Aggarwal and Stuart Turville, Kirby Institute, University of New South Wales
source : PLoS Pathogens june 2012